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파킨슨병 모델 쥐에서 보행활동저하가 뒷다리근에 미치는 영향

 Effect of Decreased Locomotor Activity on Hindlimb Muscles in a Rat Model of Parkinson’s Disease

Journal of Korean Academy of Nursing 2010년 40권 4호 p.580 ~ 588
KMID : 0806120100400040580
김용범 ( Kim Yong-Bum ) - Bredin institute Edmonton, AB Canada

최명애 ( Choe Myoung-Ae ) - 서울대학교 간호대학

Abstract

Purpose: The purpose of this study was to examine effects of decreased locomotor activity on mass, Type I and II fiber cross-sectional areas of ipsilateral and contralateral hindlimb muscles 21 days after establishing the Parkinson’s disease rat model.

Methods: The rat model was established by direct injection of 6-hydroxydopamine (6-OHDA, 50 μg) into the left substantia nigra after stereotaxic surgery. Adult male Sprague-Dawley rats were assigned to one of two groups; the Parkinson’s disease group (PD; n=17) and a sham group (S; n=8). Locomotor activity was assessed before and 21 days after the experiment. At 22 days after establishing the rat model, all rats were anesthetized and soleus and plantaris muscles were dissected from both ipsilateral and contralateral sides. The brain was dissected to identify dopaminergic neuronal death of substantia nigra in the PD group.

Results: The PD group at 21 days after establishing the Parkinson’s disease rat model showed significant decrease in locomotor activity compared with the S group. Weights and Type I and II fiber cross-sectional areas of the contralateral soleus muscle of the PD group were significantly lower than those of the S group.

Conclusion: Contralateral soleus muscle atrophy occurs 21 days after establishing the Parkinson’s disease rat model.
KeyWords
편측 파킨슨병 모델 쥐, 뒷다리근, 근위축
Parkinson’s disease, Rats, Hindlimb, Muscle atrophy
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SCI(E) MEDLINE 학술진흥재단(KCI) KoreaMed